Michael van Stipdonk

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Department of Chemistry and Biochemistry, Duquesne University
Ph.D., Chemistry, Texas A&M University, 1994

Undergraduate and graduate students in the van Stipdonk research group use ion trap mass spectrometry, spectroscopy and theory to study a variety of chemical processes in the gas-phase. As summarized below, our current research projects can be grouped into three general areas: (a) fundamental studies of peptide ion dissociation to support application of tandem mass spectrometry (tandem MS) to peptide and protein identification in proteomics; (b) studies of the intrinsic stability and reactivity of metal ion complexes important to biology, energy production and the environment, and (c) vibrational spectroscopy of gas-phase ions using wavelength-selective infrared multiple-photon photodissociation. Besides extensive use of mass spectrometry and tandem MS, work in our laboratory involves the synthesis of model molecules and peptides, including those with isotope labels, and use of density functional theory (DFT) to predict ion structures, energies and vibrational spectra. Our work on tandem MS and peptide dissociation has been funded by the National Science Foundation (NSF). Studies of intrinsic metal ion chemistry have been supported by the U.S. Department of Energy and the Idaho National Laboratory. Work on ion spectroscopy is supported in part by the NSF, the Institue for Molecules and Materials, Radboud University Nijmegen; and the Nederlandse Organisatie voor Wetenschappelijk Onderzoek. 

Selected Publications: 
  1. "Equatorial coordination of uranyl: Correlating ligand charge donation with the Oyl-U-Oyl asymmetric stretch frequency," John K. Gibson, Wibe A. de Jong, Michael J. van Stipdonk, Jonathan Martens, Giel Berden, Jos Oomens, Journal of Organometallic Chemistry (2017)
  2. "Cleaving Off Uranyl Oxygens through Chelation: A Mechanistic Study in the Gas Phase," Rebecca J. Abergel, Wibe A. de Jong, Gauthier J.-P. Deblonde, Phuong D. Dau, Ilya Captain, Teresa M. Eaton, Jiwen Jian, Michael J. van Stipdonk, Jonathan Martens, Giel Berden, Jos Oomens and John K. Gibson, Inorg. Chem. (2017)
  3. "Revealing Disparate Chemistries of Protactinium and Uranium. Synthesis of the Molecular Uranium Tetroxide Anion, UO4," Wibe A. de Jong, Phuong D. Dau, Richard E. Wilson, Joaquim Marçalo, Michael J. Van Stipdonk, Theodore A. Corcovilos, Giel Berden, Jonathan Martens, Jos Oomens, and John K. Gibson, Inorg. Chem 56, 3686 (2017)
  4. "Electronic structure and characterization of a uranyl di-15-crown-5 complex with an unprecedented sandwich structure," Shu-Xian Hu, John K. Gibson, Wan-Lu Li, Michael J. Van Stipdonk, Jonathan Martens, Giel Berden, Britta Redlich, Jos Oomens de and Jun Li, Chem. Commun. 52, 12761 (2016)
  5. "Gas Phase Reactions of Ions Derived from Anionic Uranyl Formate and Uranyl Acetate Complexes," Evan Perez, Cassandra Hanley, Stephen Koehler, Jordan Pestok, Nevo Polonsky, and Michael J. Van Stipdonk, J. Am. Soc. Mass Spectrom. 27, 1989 (2016)
  6. "Collision-induced dissociation of uranyl-methoxide and uranyl-ethoxide cations: Formation of UO2H+ and uranyl-alkyl productions," Michael J. Van Stipdonk, Cassandra Hanley, Evan Perez, Jordan Pestok, Patricia Mihm, and Theodore A. Corcovilos, Rapid Commun. Mass Spectrom. 30, 1879 (2016)
Most Cited Publications: 
  1. "Calcium Phosphate Phase Identification Using XPS and Time-of-Flight Cluster SIMS," C C Chusuei, D W Goodman, M J Van Stipdonk, D R Justes, E A Schweikert, Analytical chemistry 71, 149 (1999)
  2. "Sequence-Scrambling Fragmentation Pathways of Protonated Peptides," C Bleiholder, S Osburn, T D Williams, S Suhai, M Van Stipdonk, A G Harrison and B. Paizs, Journal of the American Chemical Society 130, 17774 (2008)
  3. "A Comparison of Desorption Yields from C+60 to Atomic and Polyatomic Projectiles at keV Energies," E A Schweikert, M J van Stipdonk, R D Harris, Rapid communications in mass spectrometry 10, 1987 (1996)
  4. "Infrared Spectroscopy of Fragments of Protonated Peptides: Direct Evidence for Macrocyclic Structures of b5 Ions  ," U Erlekam, B J Bythell, D Scuderi, M Van Stipdonk, B Paizs, P Maître, Journal of the American Chemical Society "131, 11503 (2009)
  5. "Spectroscopic Evidence for an Oxazolone Structure of the b2 Fragment Ion from Protonated Tri-Alanine ," J Oomens, S Young, S Molesworth, M van Stipdonk, Journal of the American Society for Mass Spectrometry 20, 334 (2009)

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