Carnegie Mellon University

Molecular Phenotypes of Structurally Homologous ETS Transcriptions Factors

Speaker(s): 
Gregory Poon
Dates: 
Thursday, September 28, 2017 - 4:30pm

 ETS transcription factors comprise an evolutionarily related family of genetic regulators that are ubiquitous in animals and control a myriad of physiologically critical processes. ETS proteins are united by a highly conserved DNA-binding domain, with overlapping target DNA preferences on the one hand, but are functionally diverse and non-redundant on the other. This so-called ìspecificity conundrumî besets not only our understanding of ETS homologs but also the structure-activity relationships of eukaryotic transcription factors in general. Translationally, it hampers efforts to develop...

The Hall Effects Edwin Hall Never Imagined

Speaker(s): 
Xiaofeng Jin
Dates: 
Thursday, September 14, 2017 - 4:30pm

The anomalous Hall Effect (AHE) is one of the oldest and most prominent transport phenomena in magnetic materials. However, the microscopic mechanism of the AHE has remained unresolved for more than a century because its rich phenomenology defies standard classification, prompting conflicting claims of the dominant processes. We differentiate these processes through temperature--‐dependent measurements on epitaxial Fe, Ni, Co, and NixCu1--‐x  Films of varying thickness [1],  [2]. The results allow an unambiguous identification of both intrinsic and extrinsic mechanisms of the anomalous...