Jill Millstone

Department of Chemistry, University of Pittsburgh
Ph.D., Northwestern University, 2008
Summary:

Inorganic and Materials Chemistry; Nanomaterials; Mechanochemistry; Surface and Colloid Chemistry

Whether they will be used in catalysis or artificial limbs, nanoparticle surfaces influence every aspect of their behavior. The ligand shell of a nanocrystal can determine its luminescence, its performance in a solar cell, or its clearance from the human body – to name just a few examples. In the Millstone group, we are interested in synthetically controlling this nanoparticle surface architecture – both the crystallographic and chemical composition – in order to develop new nanoparticle morphologies and reaction mechanisms that will have applications in fields ranging from catalysis to medicine.

Colloidal Nanoparticle Alloys: From bronze to steel, alloyed materials have defined the technological capabilities of their times, and like their monometallic counterparts, can experience dramatic changes in their physical properties at the nanoscale. Small, multimetallic nanoparticles (diameter = 1-5 nm) promise to provide improved catalysts for efficient use of fossil fuel resources as well as multifunctional tools in biomedical applications. However, current methods to prepare discrete, multimetallic particles afford limited tunability of particle composition, especially with respect to selectivity between alloyed, core-shell and Janus architectures. We use particle surface chemistry to control nanoparticle composition and elucidate both the synthesis and the resulting materials using a wide variety of electron microscopy and molecular characterization techniques. 

Multifunctional Nanoparticle Synthesis:  It is well known that the physical properties of nanoscale materials are highly dependent on their morphology. However, there is currently no systematic way to design and then rationally access a particular nanoparticle architecture. Elucidating these pathways would allow us to better use our current materials, and more effectively tailor new ones. Just as organic chemistry research has developed a mechanistic framework and synthetic toolbox that has produced everything from plastics to pharmaceuticals, so too must these concepts be developed for nanochemistry in order to harness the similar potential of nanomaterials. Through the discovery of nanoparticle reaction mechanisms, we work to develop a set of physical, analytical, and synthetic principles to rationally generate complex, highly-tailored nanoparticles for environmental remediation and catalysis applications.

Mechanochemistry of nanoparticles: At the nanoscale, the interplay between mechanical forces and physical properties is likely exaggerated compared to bulk materials. We are interested in understanding how mechanical forces can be used to manipulate the chemical reactivity of nanostructures. We will work to understand the response of anisotropic nanoparticles to mechanical stresses, and establish how mechanical perturbation can be used as a new type of synthetic tool in the development and application of nanomaterials.

Students
Name Positionsort ascending Email
Killinger, Jack Undergraduate Student jrk140@pitt.edu
McHugh, Kaitlyn Undergraduate Student kmm328@pitt.edu
Gan, Xing Yee Graduate Student xig39@pitt.edu
Eikey, Emily Graduate Student eae40@pitt.edu
Moncure, Paige Graduate Student pam126@pitt.edu
Sen, Riti Graduate Student ris62@pitt.edu
Simon, Zoe Graduate Student zcs12@pitt.edu
Perris, Brianna Graduate Student blp62@pitt.edu

Nathan Diemler

Graduate Student

nathan.diemler@pitt.edu
219 Parkman Avenue, Pittsburgh PA, 15260

Affiliation:

Chemistry
University of Pittsburgh

Emily Eikey

Graduate Student

eae40@pitt.edu
1005A Chevron Science Center, Pittsburgh PA, 15213

Affiliation:

Chemistry
University of Pittsburgh

Xing Yee Gan

Graduate Student

xig39@pitt.edu
219 Parkman Avenue, Pittsburgh PA, 15260
970-488-9999

Affiliation:

Chemistry
University of Pittsburgh

Project:

Synthesis and Optoelectronic Characterization of Plasmonic Non-noble Metal Nanoparticles

Jack Killinger

Undergraduate Student

jrk140@pitt.edu
219 Parkman Ave, Pittsburgh PA, 15213

Affiliation:

Chemistry
University of Pittsburgh

Kaitlyn McHugh

Undergraduate Student

kmm328@pitt.edu
219 Parkman Ave, Pittsburgh PA, 15213

Affiliation:

Chemistry
University of Pittsburgh

Paige Moncure

Graduate Student

pam126@pitt.edu
1005A Chevron Science Center, Pittsburgh PA, 15213

Affiliation:

Chemistry
University of Pittsburgh

Brianna Perris

Graduate Student

blp62@pitt.edu
219 Parkman Ave, Pittsburgh PA, 15213

Affiliation:

Chemistry
University of Pittsburgh

Bo Ryoo

Graduate Student

bor3@pitt.edu
1005A Chevron Science Center, Pittsburgh PA, 15213

Affiliation:

Chemistry
University of Pittsburgh

Riti Sen

Graduate Student

ris62@pitt.edu
Chevron Science Center, Pittsburgh PA, 15260

Affiliation:

Chemistry
University of Pittsburgh

Education:

  • B.S./B.Sc., Chemistry, Jadavpur University, 2017
  • MSc, Chemistry, Jadavpur University, 2019

Project:

Nanomaterials synthesis and characterization

Zoe Simon

Graduate Student

zcs12@pitt.edu
219 Parkman Ave, Pittsburgh PA, 15213

Affiliation:

Chemistry
University of Pittsburgh
Most Cited Publications
  1. "Observation of a quadrupole plasmon mode for a colloidal solution of gold nanoprisms." Jill E Millstone, Sungho Park, Kevin L Shuford, Lidong Qin, George C Schatz, Chad A Mirkin. Journal of the American Chemical Society.
  2. "Colloidal gold and silver triangular nanoprisms." Jill E Millstone, Sarah J Hurst, Gabriella S Metraux, Joshua I Cutler, Chad A Mirkin. small.
  3. "Rationally designed nanostructures for surface-enhanced Raman spectroscopy." Matthew J Banholzer, Jill E Millstone, Lidong Qin, Chad A Mirkin. Chemical Society Reviews.
  4. "Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles." David A Giljohann, Dwight S Seferos, Pinal C Patel, Jill E Millstone, Nathaniel L Rosi, Chad A Mirkin. Nano letters.
  5. "The role radius of curvature plays in thiolated oligonucleotide loading on gold nanoparticles." Haley D Hill, Jill E Millstone, Matthew J Banholzer, Chad A Mirkin. ACS nano.
Recent Publications
  1. "Zinc-Adeninate Metal–Organic Framework: A Versatile Photoluminescent Sensor for Rare Earth Elements in Aqueous Systems." Scott E Crawford, Xing Yee Gan, Peter CK Lemaire, Jill E Millstone, John P Baltrus, Paul R Ohodnicki Jr. ACS sensors.
  2. "Redefining the Experimental and Methods Sections." Jill E Millstone, Warren CW Chan, Cherie R Kagan, Luis M Liz-Marzán, Nicholas A Kotov, Paul A Mulvaney, Wolfgang J Parak, Andrey L Rogach, Paul S Weiss, Raymond E Schaak. ACS nano.
  3. "Announcing the 2019 ACS Nano Award Lecture Laureates." Holly Bunje, Jill E Millstone, Guangjun Nie, Andrew TS Wee, Tanja Weil, Sergey N Shmakov, Paul S Weiss. ACS nano.
  4. "Plasmon-Enhanced Chemical Conversion Using Copper Selenide Nanoparticles." Xing Yee Gan, Emily L Keller, Christopher L Warkentin, Scott E Crawford, Renee R Frontiera, Jill E Millstone. Nano letters.
  5. "Surface Chemistry-Mediated Near-Infrared Emission of Small Coinage Metal Nanoparticles." Scott E Crawford, Michael J Hartmann, Jill E Millstone. Accounts of chemical research.

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