Sean Garrett-Roe

Department of Chemistry, University of Pittsburgh
Ph.D., Physical Chemistry, University of California Berkeley, 2005
Summary:

An urgent problem in protein science is to understand ion uptake and ion recognition (selectivity) by proteins and polypeptides. This impacts proteins ranging from ion channels to ion sensors to metalloregulatory proteins to metallo-enzymes. Why and how are these bio-nanostructures so exquisitely sensitive to particular ions? How do local changes in the binding pockets lead to global conformational change? These questions have major implications for biology, and they need an answer from physical chemistry. In a separate field, that of green chemistry, there is another pressing problem to understand structural and dynamical heterogeneity in ionic liquids. What does this proposed heterogeneity imply about the solvation properties of these new "designer solvents''? Can we measure it? Can we use it to tune the solvent's properties? Better understanding the chemical physics of these systems will aid the rational design of new solvents, which in turn will have industrial consequences. There is an underlying connection between these biophysical and chemical physics questions – to really probe the mechanisms in operation, one must be able to separate static and dynamic heterogeneity. The nonliear spectroscopies developed in the Garrett-Roe lab can do exactly this. Multidimensional infrared spectroscopy can reveal structural dynamics on timescales spanning femtosecond–microseconds, and make molecular movies as reported by vibrational frequencies. These techniques will clarify

  1. The mechanism of ion selectivity in selectivity filter of an archetypal biological ion channel (KcsA).
  2. The conformational dance of guest and host in the molecular recognition of ionophores such as valinomycin.
  3. The binding of calcium ions in a biological ion sensor, EF hand, in a time- and reside-resolved way. Calcium uptake is a key step of many cellular signalling processes and is unexplored on a submicrosecond timescale.
  4. The structural and dynamical heterogeneity of ionic liquids. These fluids are a fascinating arena to move towards a deeper understanding of complex fluids.

Each of these experiments requires a combination of experimental expertise in the non-linear spectroscopy as well as skill modelling stochastic dynamics on a complex free energy landscape.

Students
Namesort descending Position Email
Brinzer, Thomas Graduate Student thomas.brinzer@pitt.edu
Coate, Emma Undergraduate Student
Dutta, Samrat Postdoctoral Fellow sad114@pitt.edu
Johnson, Clinton Graduate Student caj52@pitt.edu
Kelly, Jordan Undergraduate Student
Mitra, Sunayana Graduate Student sum57@pitt.edu
Ren, Zhe Graduate Student zhr3@pitt.edu
Wagner, Molly Undergraduate Student

Thomas Brinzer


Graduate Student

thomas.brinzer@pitt.edu
219 Parkman Avenue, Pittsburgh PA, 15260
412-715-7554

Affiliation:

Chemistry
University of Pittsburgh

Project:

Ultrafast vibrational dynamics of carbon dioxide dissolved in ionic liquids, interrogated by two-dimensional infrared spectroscopy (2D-IR)

Emma Coate


Undergraduate Student


216 Eberly Hall, Pittsburgh PA, 15260

Affiliation:

Chemistry
University of Pittsburgh

Samrat Dutta


Postdoctoral Fellow

sad114@pitt.edu
219 Parkman Avenue, Pittsburgh PA, 15260

Affiliation:

Chemistry
University of Pittsburgh

Clinton Johnson


Graduate Student

caj52@pitt.edu
219 Parkman Avenue, Pittsburgh PA, 15260

Affiliation:

Chemistry
University of Pittsburgh

Project:

Ultrafast Vibrational Spectroscopy on BH4- and Protic Ionic Liquids

Jordan Kelly


Undergraduate Student


216 Eberly Hall, Pittsburgh PA, 15260

Affiliation:

Chemistry
University of Pittsburgh

Sunayana Mitra


Graduate Student

sum57@pitt.edu
219 Parkman Avenue, Pittsburgh PA, 15260
412-918-9625

Affiliation:

Chemistry
University of Pittsburgh

Project:

Metal-Ion interaction with small biological model systems

Zhe Ren


Graduate Student

zhr3@pitt.edu
219 Parkman Avenue, Pittsburgh PA, 15260

Affiliation:

Chemistry
University of Pittsburgh

Websites:

Molly Wagner


Undergraduate Student


216 Eberly Hall, Pittsburgh PA, 15260

Affiliation:

Chemistry
University of Pittsburgh
Most Cited Publications
  1. "Electron Solvation in Two Dimensions," A. D. Miller, I. Bezel, K. J. Gaffney, S. Garrett-Roe, S. H. Liu, P. Szymanski, C. B. Harris, Science 297, 1163 (2002)
  2. "Time- and angle-resolved two-photon photoemission studies of electron localization and solvation at interfaces," P. Szymanski1, S. Garrett-Roe, C.B. Harris, Progress in Surface Science 78, 1 (2005)
  3. "Intermolecular zero-quantum coherence imaging of the human brain," Rahim R. Rizi, Sangdoo Ahn, David C. Alsop, Sean Garrett-Roe, Marlene Mescher, Wolfgang Richter, Mitchell D. Schnall, John S. Leigh, Warren S. Warren, Magnetic Resonance in Medicine 43, 627 (2000)
  4. "Purely absorptive three-dimensional infrared spectroscopy," Sean Garrett-Roe and Peter Hamm, J. Chem. Phys. 130, 164510 (2009)
  5. "Three-dimensional infrared spectroscopy of isotope-substituted liquid water reveals heterogeneous dynamics," Sean Garrett-Roe, Fivos Perakis, Francesco Rao, Peter Hamm.  The Journal of Physical Chemistry B 115, no. 21 (2011): 6976-6984.
Recent Publications
  1. "Modeling Carbon Dioxide Vibrational Frequencies in Ionic Liquids: III. Dynamics and Spectroscopy," Thomas Brinzer, Clyde A. Daly, Cecelia Allison, Sean Garrett-Roe, and Steven A. Corcelli, J. Phys. Chem. B (2018)
  2. "Temperature and chain length dependence of ultrafast vibrational dynamics of thiocyanate in alkylimidazolium ionic liquids: A random walk on a rugged energy landscape", Thomas Brinzer, and Sean Garrett-RoeThe Journal of Chemical Physics 147, 194501 (2017)
  3. "Sub-10 Nanometer Feature Size in Silicon Using Thermal Scanning Probe Lithography", Yu Kyoung Ryu Cho, Colin D. Rawlings, Heiko Wolf, Martin Spieser, Samuel Bisig, Steffen Reidt, Marilyne Sousa, Subarna R. Khanal, Tevis D. B. Jacobs, and Armin W. Knoll, ACS Nano (2017)
  4. "Ultrafast dynamics of ionic liquids in colloidal dispersion", Zhe Ren,  Jordan Kelly,  Chaminda Prasad Gunathilaka,  Thomas Brinzer,  Samrat Dutta,  Clinton A Johnson,  Sunayana Mitra  and  Sean Garrett-RoePhys. Chem. Chem. Phys.  (2017)
  5. "Reorientation-induced spectral diffusion of non-isotropic orientation distributions," Zhe Ren, and Sean Garrett-Roe, The Journal of Chemical Physics 147, 144504 (2017)
  6. "Modeling Carbon Dioxide Vibrational Frequencies in Ionic Liquids: I. Ab Initio Calculations," Eric J. Berquist, Clyde A. Daly Jr., Thomas Brinzer, Krista K. Bullard, Zachary M. Campbell, Steven A. Corcelli, Sean Garrett-Roe, and Daniel S. Lambrecht, J. Phys. Chem. B, 121, 208 (2017)

More Members