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Saxena Lab Reports New Method for Efficient Analysis of Protein Structure and Dynamics

Physical Chemistry Chemical Physics cover

A research article published from the lab of Prof. Sunil Saxena has been featured on the cover of a recent issue of the journal Physical Chemistry Chemical Physics. The accompanying paper reports new methodology for the analysis of proteins by electron paramagnetic resonance (EPR) spectroscopy. Pulsed EPR is a powerful method for probing structure and dynamics in biomacromolecules; however, these measurements are often complicated by issues arising from orientational effects of the spin labels required for the measurement. In their paper, Saxena and graduate student coauthors Zikri Hasanbasri and Nicholas Moriglioni report a new optimized data acquisition and analysis scheme that mitigates these effects and enables efficient pulsed EPR experiments on complex samples.

From Pitt Chemistry